SYNkinase: Your first choice for small molecule inhibitors

EPZ-6438

SYN-3045 | CAS 1403254-99-8

Inactivation of the switch/sucrose nonfermentable complex component SMARCB1 is extremely prevalent in pediatric malignant rhabdoid tumors (MRTs) or atypical teratoid rhabdoid tumors. EPZ-6438 induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells.

Treatment of xenograft-bearing mice with EPZ-6438 leads to dose-dependent regression of MRTs with correlative diminution of intratumoral trimethylation levels of lysine 27 on histone H3, and prevention of tumor regrowth after dosing cessation.

Availability
In stock
Technical Data
Cas 1403254-99-8
Alternative Names EPZ6438
Salt wt. N/A
References Ref.1
Ref.2
Api wt. 572.75
Formula C34H44N4O4
Related Pathways
Purity >95%

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