SYNkinase: Your first choice for small molecule inhibitors

Selonsertib Hydrochloride

SYN-1229 | CAS 1448428-05-4

Selonsertib, also known as GS-4997, is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities.

GS-4997 targets and binds to the catalytic kinase domain of ASK1 in an ATP-competitive manner. GS-4997 prevents the production of inflammatory cytokines, down-regulates the expression of genes involved in fibrosis, suppresses excessive apoptosis and inhibits cellular proliferation.

Availability
In stock
Technical Data
Cas 1448428-05-4
Alternative Names Selonsertib, GS-4997
Salt wt. 481.96
References Ref.1
Ref.2
Api wt. 445.50
Formula C24H25ClFN7O.HCl
Related Pathways
Purity >95%

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