SYNkinase: Your first choice for small molecule inhibitors

TGFb/SMAD

Transforming growth factor beta is involved in many cellular processes. The TGFβ superfamily ligands bind to a type II receptor, which recruits and phosphorylates a type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs.

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AKT GSK3
GSK3

SYNkinase Products: SYN-1075

Involved in pathways: NF-kB, mTOR, BTK

Interacts with: NF-kB

UniProt
Protein Databank
PDK1
PDK1

SYNkinase Products: SYN-1027, SYN-1009

Involved in pathways: NF-kB, mTOR

Interacts with: PI3K, AKT

UniGene
UniProt
Protein Databank
PI3K PKA
PKA

SYNkinase Products: SYN-1110

Involved in pathways: NF-kB, GPCR

Interacts with: NF-kB

Protein Databank
PKC
PKC

SYNkinase Products: SYN-1021, SYN-1037

Involved in pathways: NF-kB, TGFb/SMAD, GPCR

Interacts with: NF-kB

UniGene
UniProt
Protein Databank
RSK
RSK

SYNkinase Products: SYN-1020, SYN-1124

Involved in pathways: NF-kB

Interacts with: NF-kB

UniGene
UniProt
Protein Databank
ABL
ABL

SYNkinase Products: SYN-1095

Involved in pathways: TGFb/SMAD

Interacts with: PAK,

UniGene
UniProt
Protein Databank
AKT JNK
JNK

SYNkinase Products: SYN-1147, SYN-1028

Involved in pathways: TGFb/SMAD, MAP Kinase, GPCR, BTK

Interacts with: MKK4, JAK

Protein Databank
LIMK
LIMK

SYNkinase Products: SYN-1023

Involved in pathways: TGFb/SMAD

Interacts with: ROCK

UniGene
UniProt
Protein Databank
MEK1
MEK1

SYNkinase Products: SYN-1031, SYN-1170, SYN-1059, SYN-1016, SYN-1188, SYN-1195

Involved in pathways: TGFb/SMAD

Interacts with: Raf, ERK1/2

UniGene
UniProt
Protein Databank
MEK2
MEK2

SYNkinase Products: SYN-1031, SYN-1170, SYN-1059, SYN-1016, SYN-1188, SYN-1195

Involved in pathways: TGFb/SMAD

Interacts with: Raf, WRK1/2

UniGene
UniProt
Protein Databank
mTOR PI3K PKC
PKC

SYNkinase Products: SYN-1021, SYN-1037, SYN-1172

Involved in pathways: NF-kB, TGFb/SMAD, GPCR

Interacts with: Par6

UniGene
UniProt
Protein Databank
Raf
Raf

SYNkinase Products: SYN-1169, SYN-1168

Involved in pathways: TGFb/SMAD, JAK-STAT, GPCR

Interacts with: Ras, MEK1,2

UniGene
UniProt
Protein Databank
Rho
Rho

SYNkinase Products: SYN-1071

Involved in pathways: TGFb/SMAD

Interacts with:

UniGene
UniProt
Protein Databank
ROCK
ROCK

SYNkinase Products: SYN-1083

Involved in pathways: TGFb/SMAD

UniGene
UniProt
Protein Databank
S6K
S6K

SYNkinase Products: SYN-1132, SYN-1177

Involved in pathways: TGFb/SMAD, mTOR

Interacts with: mTOR, PP2A

UniGene
UniProt
Protein Databank
AKT EGFR
EGFR

SYNkinase Products: SYN-1012, SYN-1030, SYN-1039, SYN-1042, SYN-1100, SYN-1142, SYN-1052, SYN-1140, SYN-1141, SYN-1153, SYN-1090, SYN-1192

Involved in pathways: JAK-STAT, Epigenetic

Interacts with: EGF, STAT

JAK MEK
MEK

SYNkinase Products: SYN-1031, SYN-1170, SYN-1059, SYN-1016, SYN-1188, SYN-1190, SYN-1195

Involved in pathways: JAK-STAT

Interacts with: Raf, ERK

UniGene
UniProt
Protein Databank
mTOR PI3K Raf
Raf

SYNkinase Products: SYN-1169, SYN-1168

Involved in pathways: TGFb/SMAD, JAK-STAT, GPCR

Interacts with: RAS, MEK

UniGene
UniProt
Protein Databank
A-Raf, B-Raf
A-Raf, B-Raf

SYNkinase Products: SYN-1069, SYN-1077, SYN-1161, SYN-1082,

Involved in pathways: MAP Kinase

Interacts with: EGFR, MEK1,2 ERK1,2

UniGene
UniProt
Protein Databank
JNK1-3
JNK1-3

SYNkinase Products: SYN-1147, SYN-1028

Interacts with: MKK4,7, JNK1-3

Protein Databank
MEK1,2
MEK1,2

SYNkinase Products: SYN-1031, SYN-1170, SYN-1059, SYN-1016, SYN-1188, SYN-1190, SYN-1195

Involved in pathways: MAP Kinase, Epigenetic

Interacts with: A-Raf, B-Raf, TLP2, ERK1,2

UniGene
UniProt
Protein Databank
MEK5
MEK5

SYNkinase Products: SYN-1031, SYN-1170, SYN-1059, SYN-1016, SYN-1188, SYN-1190, SYN-1195

Involved in pathways: MAP Kinase

Interacts with: GPCR, ERK3-5,7,8

UniGene
UniProt
MKK3,6
MKK3,6

SYNkinase Products: SYN-1031, SYN-1059, SYN-1016

Involved in pathways: MAP Kinase

Interacts with: TAK1, p38alpha, beta, gamma, sigma

UniGene
UniProt
MKK4,7
MKK4,7

SYNkinase Products: SYN-1031, SYN-1059, SYN-1016

Involved in pathways: MAP Kinase

Interacts with: TAO1,2 Domains, JNK1-3

UniGene
UniProt
P38 (alpha, beta, gamma, sigma)
P38 (alpha, beta, gamma, sigma)

SYNkinase Products: SYN-1101, SYN-1072, SYN-1073, SYN-1073A, SYN-1074, SYN-1076, SYN-1078, SYN-1079, SYN-1087, SYN-1093, SYN-1123,

Involved in pathways: MAP Kinase, BTK, GPCR

Interacts with: MKK3,6, MAPKAPK2,3,5

Protein Databank
RSK1-3
RSK1-3

SYNkinase Products: SYN-1020, SYN-1124

Involved in pathways: MAP Kinase, Epigenetic

Interacts with: ERK3-5,7,8

UniGene
UniProt
Protein Databank
MEK4,7
MEK4,7

SYNkinase Products:

AKT
AKT

SYNkinase Products: SYN-1110, SYN-1005, SYN-1006, SYN-1160, SYN-1043, SYN-1118, SYN-1162, SYN-1131

Involved in pathways: NF-kB, mTOR, BTK, TGFb/SMAD, JAK-STAT

Interacts with: PDK1, PIP3, mTORC2, TSC1/2, MDM2, IKK, BAD, ASK-1, FOXO, GSK3

UniGene
UniProt
Protein Databank
GSK3
GSK3

SYNkinase Products: SYN-1075

Involved in pathways: NF-kB, mTOR, BTK

Interacts with: AKT

UniProt
Protein Databank
HER
HER

SYNkinase Products: SYN-1075

Involved in pathways: mTOR

Interacts with: EGF, GRB2

Protein Databank
mTOR
mTOR

SYNkinase Products: SYN-1167, SYN-1166, SYN-1157, SYN-1050, SYN-1181, SYN-1150, SYN-1148, SYN-1178, SYN-1178A, SYN-1186, SYN-1194

Involved in pathways: TGFb/SMAD, mTOR, JAK-STAT

Interacts with: mLST8, SIN1, Protor, Rictor, raptor, PRAS40

UniGene
UniProt
Protein Databank
mTOR
mTOR

SYNkinase Products: SYN-1167, SYN-1166, SYN-1157, SYN-1050, SYN-1181, SYN-1150, SYN-1148, SYN-1178, SYN-1178A, SYN-1186, SYN-1194

Involved in pathways: TGFb/SMAD, mTOR, JAK-STAT

Interacts with: mLST8, SIN1, Protor, Rictor, raptor, PRAS40

UniGene
UniProt
Protein Databank
PDK1
PDK1

SYNkinase Products: SYN-1027, SYN-1009

Involved in pathways: NF-kB, mTOR

Interacts with: PIP3, S6K, AKT

UniGene
UniProt
Protein Databank
PDK1
PDK1

SYNkinase Products: SYN-1027, SYN-1009

Involved in pathways: NF-kB, mTOR

Interacts with: PIP3, S6K, AKT

UniGene
UniProt
Protein Databank
PI3K S6K1
S6K1

SYNkinase Products: SYN-1132, SYN-1177

Interacts with: mTORC1, PDK1, IRS1, eIF4B, S6, PDCD4 eEF2K

UniGene
UniProt
Protein Databank
AKT
AKT

SYNkinase Products: SYN-1110, SYN-1005, SYN-1006, SYN-1160, SYN-1043, SYN-1118, SYN-1162, SYN-1131

Involved in pathways: NF-kB, mTOR, BTK, TGFb/SMAD, JAK-STAT

Interacts with: p85/p110 PI3K, GSK3

UniGene
UniProt
Protein Databank
BCR
BCR

SYNkinase Products: SYN-1095, SYN-1046, SYN-1061, SYN-1025, SYN-1036, SYN-1057, SYN-1116, SYN-1179, SYN-1122

Involved in pathways: BTK

Interacts with: Igalpha, Igbeta

BTK
BTK

SYNkinase Products: SYN-1164, SYN-1171, SYN-1036, SYN-1184

Involved in pathways: BTK

Interacts with: ptdins(3,4,5)P3, LYN, SYK, BLINK

UniGene
UniProt
Protein Databank
GSK3
GSK3

SYNkinase Products: SYN-1075

Involved in pathways: NF-kB, mTOR, BTK

Interacts with: AKT, NFAT

UniProt
Protein Databank
JNK
JNK

SYNkinase Products: SYN-1147, SYN-1028

Involved in pathways: TGFb/SMAD, MAP Kinase, GPCR, BTK

Interacts with: PKC

Protein Databank
P38 (alpha, beta, gamma, sigma)
P38 (alpha, beta, gamma, sigma)

SYNkinase Products: SYN-1101, SYN-1072, SYN-1073, SYN-1073A, SYN-1074, SYN-1076, SYN-1078, SYN-1079, SYN-1087, SYN-1093, SYN-1123

Involved in pathways: MAP Kinase, BTK, GPCR

Interacts with: Ca2+

Protein Databank
PKCalpha
PKCalpha

SYNkinase Products: SYN-1021, SYN-1037, SYN-1172

Involved in pathways: BTK

Interacts with: DAG, ERK,JNK

UniGene
UniProt
Protein Databank
SYK
SYK

SYNkinase Products: SYN-1121, SYN-1122

Involved in pathways: BTK

Interacts with: LYN, Igbeta, SHP1, BTK, BLINK, p85/p110 PI3K

UniGene
UniProt
Protein Databank
Abl
Abl

SYNkinase Products: SYN-1095, SYN-1046, SYN-1061, SYN-1025, SYN-1036, SYN-1057, SYN-1116, SYN-1180A

Involved in pathways:

Interacts with: Cyclin D, CDK4,5, E2F, DP, Rb, HDAC, CDK2,

UniGene
UniProt
Protein Databank
Abl
Abl

SYNkinase Products: SYN-1095, SYN-1046, SYN-1061, SYN-1025, SYN-1036, SYN-1057, SYN-1116, SYN-1180A

Involved in pathways:

Interacts with: Cyclin D, CDK4,5, E2F, DP, Rb, HDAC, CDK2,

UniGene
UniProt
Protein Databank
ATM/ATR
ATM/ATR

SYNkinase Products: SYN-1051

Involved in pathways:

Interacts with: Chk1,2, BRACA1, FANCD2, NBS1, Abl

UniGene
UniProt
Aurora A
Aurora A

SYNkinase Products: SYN-1011, SYN-1034, SYN-1095, SYN-1048, SYN-1081, SYN-1092

Involved in pathways:

Interacts with: ARF

UniGene
UniProt
Protein Databank
CDK2
CDK2

SYNkinase Products: SYN-1110, SYN-1048, SYN-1040, SYN-1010, SYN-1151, SYN-1097, SYN-1070, SYN-1080, SYN-1180A

Involved in pathways:

Interacts with: Cyclin E, p21, CDC25A, Cyclin D, CDK4,5, Abl, E2F, DP, HDAC, Rb, Cyclin A, p21, p27

UniGene
UniProt
Protein Databank
CDK2
CDK2

SYNkinase Products: SYN-1110, SYN-1048, SYN-1040, SYN-1010, SYN-1151, SYN-1097, SYN-1070, SYN-1080, SYN-1180A

Involved in pathways:

Interacts with: Cyclin E, p21, CDC25A, Cyclin D, CDK4,5, Abl, E2F, DP, HDAC, Rb, Cyclin A, p21, p27

UniGene
UniProt
Protein Databank
CDK4,5
CDK4,5

SYNkinase Products: SYN-1110, SYN-1048, SYN-1040, SYN-1010, SYN-1151, SYN-1097, SYN-1070, SYN-1080, SYN-1180A

Involved in pathways:

Interacts with: P15,16,18,19, CDC25A, Cyclin D, E2F, DB

UniGene
UniProt
Protein Databank
CDK7
CDK7

SYNkinase Products: SYN-1110, SYN-1048, SYN-1040, SYN-1010, SYN-1151, SYN-1097, SYN-1070, SYN-1080, SYN-1180A

Involved in pathways:

Interacts with: Cyckin H, CDK2, Cyclin A

UniGene
UniProt
Protein Databank
Chk1
Chk1

SYNkinase Products: SYN-1174, SYN-1173, SYN-1174, SYN1189

Involved in pathways:

Interacts with: ATM, ATR, CDC25B/C

UniGene
UniProt
Protein Databank
Chk2
Chk2

SYNkinase Products: SYN-1174, SYN-1173

Involved in pathways:

Interacts with: ATM, ATR, CDC25B/C

UniGene
UniProt
Protein Databank
DNAPKcs
DNAPKcs

SYNkinase Products: SYN-1096

Interacts with: p53

UniGene
UniProt
Protein Databank
BRaf
BRaf

SYNkinase Products: SYN-1069, SYN-1077, SYN-1161, SYN-1082

Involved in pathways: GPCR, Epigenetic

Interacts with: Epac, ERK

UniGene
UniProt
Protein Databank
JNK
JNK

SYNkinase Products: SYN-1147, SYN-1028

Involved in pathways: TGFb/SMAD, MAP Kinase, GPCR, BTK

Interacts with: RAS, SP1, c-JUN

Protein Databank
P38 PKA
PKA

SYNkinase Products: SYN-1110

Involved in pathways: NF-kB, GPCR

Interacts with: cAMP, Raf, Rap-1

Protein Databank
PKC
PKC

SYNkinase Products: SYN-1021, SYN-1037, SYN-1172

Involved in pathways: NF-kB, TGFb/SMAD, GPCR

Interacts with: PLCbeta, Raf

UniGene
UniProt
Protein Databank
PLCbeta
PLCbeta

SYNkinase Products: SYN-1172

Involved in pathways: GPCR

Interacts with: Galpha q, PKC

UniGene
UniProt
Raf
Raf

SYNkinase Products: SYN-1069, SYN-1077, SYN-1161, SYN-1082, SYN-1168

Involved in pathways: TGFb/SMAD, JAK-STAT, GPCR

Interacts with: PKC, PKA, RAS, ERK

UniGene
UniProt
Protein Databank
ARaf
ARaf

SYNkinase Products: SYN-1069, SYN-1077, SYN-1161, SYN-1082

Involved in pathways: Epigenetic

Interacts with: RAS, MEK1/2

UniGene
UniProt
Protein Databank
BRaf
BRaf

SYNkinase Products: SYN-1069, SYN-1077, SYN-1161, SYN-1082

Involved in pathways: GPCR, Epigenetic

Interacts with: RAS, MEK1/2

UniGene
UniProt
Protein Databank
CDK4
CDK4

SYNkinase Products: SYN-1110, SYN-1048, SYN-1040, SYN-1010, SYN-1151, SYN-1097, SYN-1070, SYN-1080, SYN-1180A

Involved in pathways: Epigenetic

Interacts with: ERK1/2, Cyclin D

UniGene
UniProt
Protein Databank
CRaf
CRaf

SYNkinase Products: SYN-1069, SYN-1077, SYN-1161, SYN-1082

Involved in pathways: Epigenetic

Interacts with: RAS, MEK1/2

Protein Databank
EGFR FGFR
FGFR

SYNkinase Products: SYN-1095, SYN-1134, SYN-1135, SYN-1152, SYN-1084, SYN-1029, SYN-1038, SYN-1091, SYN-1149, SYN-1116, SYN-1085, SYN-1176

Involved in pathways: Epigenetic

Interacts with: FGF, GRB2

UniGene
UniProt
HER2
HER2

SYNkinase Products: SYN-1012, SYN-1100, SYN-1142, SYN-1052, SYN-1140, SYN-1141, SYN-1153, SYN-1033, SYN-1112, SYN-1192

Involved in pathways: Epigenetic

Interacts with: HRG, GRB2

Protein Databank
MEK1/2
MEK1/2

SYNkinase Products: SYN-1031, SYN-1170, SYN-1059, SYN-1016, SYN-1188, SYN-1190, SYN-1195

Interacts with: ARaf, BRaf, CRaf, ERK1/2

UniGene
UniProt
Protein Databank
PDGFR RSK1-3
RSK1-3

SYNkinase Products: SYN-1020

Involved in pathways: MAP Kinase, Epigenetic

Interacts with: ERK1/2

UniGene
UniProt
Protein Databank