SYNkinase: Your first choice for small molecule inhibitors

Pathways

Check out SYNkinase's unique interactive pathways. They have been designed in-house, in collaboration with leading scientists, to provide you with the most up-to-date information available. They give you a new way to view SYNkinase products and provide access to relevant links like UniGene, UniProt and the Protein Data Base. We currently cover the BTK, Cell Cycle, RTK Pathway, GPCR, EGFR & JAK/STAT, MAP, PI3K/MTOR, NF-kB and TGF-β pathways. New pathways are being added all the time, so check back routinely. Of course, if you discover inaccuracies, glitches or errors, please contact us!


AKT
AKT

SYNkinase Products: SYN-1110, SYN-1005, SYN-1006, SYN-1160, SYN-1043, SYN-1118, SYN-1162, SYN-1131

Involved in pathways: NF-kB, mTOR, BTK, TGFb/SMAD, JAK-STAT

Interacts with: PDK1, IKKa

UniGene
UniProt
Protein Databank
GSK3
GSK3

SYNkinase Products: SYN-1075

Involved in pathways: NF-kB, mTOR, BTK

Interacts with: NF-kB

UniProt
Protein Databank
PDK1
PDK1

SYNkinase Products: SYN-1027, SYN-1009

Involved in pathways: NF-kB, mTOR

Interacts with: PI3K, AKT

UniGene
UniProt
Protein Databank
PI3K
PI3K

SYNkinase Products: SYN-1009, SYN-1018, SYN-1146, SYN-1041, SYN-1150, SYN-1148, SYN-1114, SYN-1115, SYN-1126, SYN-1045, SYN-1175, SYN-1108, SYN-1145, SYN-1067, SYN-1068, SYN-1066, SYN-1065, SYN-1098, SYN-1105, SYN-1089, SYN-1127, SYN-1137, SYN-1175, SYN-1178, SYN-1178A, SYN-1194

Involved in pathways: NF-kB, TGFb/SMAD, JAK-STAT, mTOR

Interacts with: TRAF2, RIP, PDK1

UniGene
UniProt
PKA
PKA

SYNkinase Products: SYN-1110

Involved in pathways: NF-kB, GPCR

Interacts with: NF-kB

Protein Databank
PKC
PKC

SYNkinase Products: SYN-1021, SYN-1037

Involved in pathways: NF-kB, TGFb/SMAD, GPCR

Interacts with: NF-kB

UniGene
UniProt
Protein Databank
RSK
RSK

SYNkinase Products: SYN-1020, SYN-1124

Involved in pathways: NF-kB

Interacts with: NF-kB

UniGene
UniProt
Protein Databank
 ABL
ABL

SYNkinase Products: SYN-1095

Involved in pathways: TGFb/SMAD

Interacts with: PAK,

UniGene
UniProt
Protein Databank
AKT
AKT

SYNkinase Products: SYN-1110, SYN-1005, SYN-1006, SYN-1160, SYN-1043, SYN-1118, SYN-1162, SYN-1131

Involved in pathways: NF-kB, mTOR, BTK, TGFb/SMAD, JAK-STAT

Interacts with: PI3K, mTOR

UniGene
UniProt
Protein Databank
JNK
JNK

SYNkinase Products: SYN-1147, SYN-1028

Involved in pathways: TGFb/SMAD, MAP Kinase, GPCR, BTK

Interacts with: MKK4, JAK

Protein Databank
LIMK
LIMK

SYNkinase Products: SYN-1023

Involved in pathways: TGFb/SMAD

Interacts with: ROCK

UniGene
UniProt
Protein Databank
MEK1
MEK1

SYNkinase Products: SYN-1031, SYN-1170, SYN-1059, SYN-1016, SYN-1188, SYN-1195

Involved in pathways: TGFb/SMAD

Interacts with: Raf, ERK1/2

UniGene
UniProt
Protein Databank
MEK2
MEK2

SYNkinase Products: SYN-1031, SYN-1170, SYN-1059, SYN-1016, SYN-1188, SYN-1195

Involved in pathways: TGFb/SMAD

Interacts with: Raf, WRK1/2

UniGene
UniProt
Protein Databank
mTOR
mTOR

SYNkinase Products: SYN-1167, SYN-1166, SYN-1157, SYN-1050, SYN-1181, SYN-1150, SYN-1148, SYN-1178, SYN-1178A, SYN-1185, SYN-1186, SYN-1194

Involved in pathways: TGFb/SMAD, mTOR, JAK-STAT

Interacts with: AKT, S6K

UniGene
UniProt
Protein Databank
PI3K
PI3K

SYNkinase Products: SYN-1009, SYN-1018, SYN-1146, SYN-1041, SYN-1150, SYN-1148, SYN-1114, SYN-1115, SYN-1126, SYN-1045, SYN-1175, SYN-1108, SYN-1145, SYN-1067, SYN-1068, SYN-1066, SYN-1065, SYN-1098, SYN-1105, SYN-1089, SYN-1127, SYN-1137, SYN-1175, SYN-1178, SYN-1178A, SYN-1194

Involved in pathways: NF-kB, TGFb/SMAD, JAK-STAT, mTOR

Interacts with: TGFbR, AKT

UniGene
UniProt
PKC
PKC

SYNkinase Products: SYN-1021, SYN-1037, SYN-1172

Involved in pathways: NF-kB, TGFb/SMAD, GPCR

Interacts with: Par6

UniGene
UniProt
Protein Databank
Raf
Raf

SYNkinase Products: SYN-1169, SYN-1168

Involved in pathways: TGFb/SMAD, JAK-STAT, GPCR

Interacts with: Ras, MEK1,2

UniGene
UniProt
Protein Databank
Rho
Rho

SYNkinase Products: SYN-1071

Involved in pathways: TGFb/SMAD

Interacts with:

UniGene
UniProt
Protein Databank
ROCK
ROCK

SYNkinase Products: SYN-1083

Involved in pathways: TGFb/SMAD

UniGene
UniProt
Protein Databank
S6K
S6K

SYNkinase Products: SYN-1132, SYN-1177

Involved in pathways: TGFb/SMAD, mTOR

Interacts with: mTOR, PP2A

UniGene
UniProt
Protein Databank
 AKT
AKT

SYNkinase Products: SYN-1110, SYN-1005, SYN-1006, SYN-1160, SYN-1043, SYN-1118, SYN-1162, SYN-1131

Involved in pathways: NF-kB, mTOR, BTK, TGFb/SMAD, JAK-STAT

Interacts with: PI3K, mTOR

UniGene
UniProt
Protein Databank
EGFR
EGFR

SYNkinase Products: SYN-1012, SYN-1030, SYN-1039, SYN-1042, SYN-1100, SYN-1142, SYN-1052, SYN-1140, SYN-1141, SYN-1153, SYN-1090, SYN-1192

Involved in pathways: JAK-STAT, Epigenetic

Interacts with: EGF, STAT

JAK
JAK

SYNkinase Products: SYN-1015, SYN-1117, SYN-1156, SYN-1158, SYN-1054, SYN-1035, SYN-1136, SYN-1120, SYN-1106, SYN-1107, SYN-1103, SYN-1104, SYN-1032, SYN-1191

Involved in pathways: JAK-STAT

Interacts with: EGFR, PI3K

UniGene
UniProt
Protein Databank
MEK
MEK

SYNkinase Products: SYN-1031, SYN-1170, SYN-1059, SYN-1016, SYN-1188, SYN-1190, SYN-1195

Involved in pathways: JAK-STAT

Interacts with: Raf, ERK

UniGene
UniProt
Protein Databank
mTOR
mTOR

SYNkinase Products: SYN-1167, SYN-1166, SYN-1157, SYN-1050, SYN-1181, SYN-1150, SYN-1148, SYN-1178, SYN-1178A, SYN-1181, SYN-1186, SYN-1194

Involved in pathways: TGFb/SMAD, mTOR, JAK-STAT

Interacts with: AKT

UniGene
UniProt
Protein Databank
PI3K
PI3K

SYNkinase Products: SYN-1009, SYN-1018, SYN-1146, SYN-1041, SYN-1150, SYN-1148, SYN-1114, SYN-1115, SYN-1126, SYN-1045, SYN-1175, SYN-1108, SYN-1145, SYN-1067, SYN-1068, SYN-1066, SYN-1065, SYN-1098, SYN-1105, SYN-1089, SYN-1127, SYN-1137, SYN-1178, SYN-1178A, SYN-1194

Involved in pathways: NF-kB, TGFb/SMAD, JAK-STAT, mTOR

Interacts with: JAK, AKT

UniGene
UniProt
Raf
Raf

SYNkinase Products: SYN-1169, SYN-1168

Involved in pathways: TGFb/SMAD, JAK-STAT, GPCR

Interacts with: RAS, MEK

UniGene
UniProt
Protein Databank
 A-Raf, B-Raf
A-Raf, B-Raf

SYNkinase Products: SYN-1069, SYN-1077, SYN-1161, SYN-1082,

Involved in pathways: MAP Kinase

Interacts with: EGFR, MEK1,2 ERK1,2

UniGene
UniProt
Protein Databank
JNK1-3
JNK1-3

SYNkinase Products: SYN-1147, SYN-1028

Interacts with: MKK4,7, JNK1-3

Protein Databank
MEK1,2
MEK1,2

SYNkinase Products: SYN-1031, SYN-1170, SYN-1059, SYN-1016, SYN-1188, SYN-1190, SYN-1195

Involved in pathways: MAP Kinase, Epigenetic

Interacts with: A-Raf, B-Raf, TLP2, ERK1,2

UniGene
UniProt
Protein Databank
MEK5
MEK5

SYNkinase Products: SYN-1031, SYN-1170, SYN-1059, SYN-1016, SYN-1188, SYN-1190, SYN-1195

Involved in pathways: MAP Kinase

Interacts with: GPCR, ERK3-5,7,8

UniGene
UniProt
MKK3,6
MKK3,6

SYNkinase Products: SYN-1031, SYN-1059, SYN-1016

Involved in pathways: MAP Kinase

Interacts with: TAK1, p38alpha, beta, gamma, sigma

UniGene
UniProt
MKK4,7
MKK4,7

SYNkinase Products: SYN-1031, SYN-1059, SYN-1016

Involved in pathways: MAP Kinase

Interacts with: TAO1,2 Domains, JNK1-3

UniGene
UniProt
P38 (alpha, beta, gamma, sigma)
P38 (alpha, beta, gamma, sigma)

SYNkinase Products: SYN-1101, SYN-1072, SYN-1073, SYN-1073A, SYN-1074, SYN-1076, SYN-1078, SYN-1079, SYN-1087, SYN-1093, SYN-1123,

Involved in pathways: MAP Kinase, BTK, GPCR

Interacts with: MKK3,6, MAPKAPK2,3,5

Protein Databank
RSK1-3
RSK1-3

SYNkinase Products: SYN-1020, SYN-1124

Involved in pathways: MAP Kinase, Epigenetic

Interacts with: ERK3-5,7,8

UniGene
UniProt
Protein Databank
MEK4,7
MEK4,7

SYNkinase Products:

AKT
AKT

SYNkinase Products: SYN-1110, SYN-1005, SYN-1006, SYN-1160, SYN-1043, SYN-1118, SYN-1162, SYN-1131

Involved in pathways: NF-kB, mTOR, BTK, TGFb/SMAD, JAK-STAT

Interacts with: PDK1, PIP3, mTORC2, TSC1/2, MDM2, IKK, BAD, ASK-1, FOXO, GSK3

UniGene
UniProt
Protein Databank
GSK3
GSK3

SYNkinase Products: SYN-1075

Involved in pathways: NF-kB, mTOR, BTK

Interacts with: AKT

UniProt
Protein Databank
HER
HER

SYNkinase Products: SYN-1075

Involved in pathways: mTOR

Interacts with: EGF, GRB2

Protein Databank
mTOR
mTOR

SYNkinase Products: SYN-1167, SYN-1166, SYN-1157, SYN-1050, SYN-1181, SYN-1150, SYN-1148, SYN-1178, SYN-1178A, SYN-1186, SYN-1194

Involved in pathways: TGFb/SMAD, mTOR, JAK-STAT

Interacts with: mLST8, SIN1, Protor, Rictor, raptor, PRAS40

UniGene
UniProt
Protein Databank
mTOR
mTOR

SYNkinase Products: SYN-1167, SYN-1166, SYN-1157, SYN-1050, SYN-1181, SYN-1150, SYN-1148, SYN-1178, SYN-1178A, SYN-1186, SYN-1194

Involved in pathways: TGFb/SMAD, mTOR, JAK-STAT

Interacts with: mLST8, SIN1, Protor, Rictor, raptor, PRAS40

UniGene
UniProt
Protein Databank
PDK1
PDK1

SYNkinase Products: SYN-1027, SYN-1009

Involved in pathways: NF-kB, mTOR

Interacts with: PIP3, S6K, AKT

UniGene
UniProt
Protein Databank
PDK1
PDK1

SYNkinase Products: SYN-1027, SYN-1009

Involved in pathways: NF-kB, mTOR

Interacts with: PIP3, S6K, AKT

UniGene
UniProt
Protein Databank
PI3K
PI3K

SYNkinase Products: SYN-1009, SYN-1018, SYN-1146, SYN-1041, SYN-1150, SYN-1148, SYN-1114, SYN-1115, SYN-1126, SYN-1045, SYN-1175, SYN-1108, SYN-1145, SYN-1067, SYN-1068, SYN-1066, SYN-1065, SYN-1098, SYN-1105, SYN-1089, SYN-1127, SYN-1137, SYN-1178, SYN-1178A, SYN-1194

Involved in pathways: NF-kB, TGFb/SMAD, JAK-STAT, mTOR

Interacts with: PIP2, PIP3

UniGene
UniProt
S6K1
S6K1

SYNkinase Products: SYN-1132, SYN-1177

Interacts with: mTORC1, PDK1, IRS1, eIF4B, S6, PDCD4 eEF2K

UniGene
UniProt
Protein Databank
 AKT
AKT

SYNkinase Products: SYN-1110, SYN-1005, SYN-1006, SYN-1160, SYN-1043, SYN-1118, SYN-1162, SYN-1131

Involved in pathways: NF-kB, mTOR, BTK, TGFb/SMAD, JAK-STAT

Interacts with: p85/p110 PI3K, GSK3

UniGene
UniProt
Protein Databank
BCR
BCR

SYNkinase Products: SYN-1095, SYN-1046, SYN-1061, SYN-1025, SYN-1036, SYN-1057, SYN-1116, SYN-1179, SYN-1122

Involved in pathways: BTK

Interacts with: Igalpha, Igbeta

BTK
BTK

SYNkinase Products: SYN-1164, SYN-1171, SYN-1036, SYN-1184

Involved in pathways: BTK

Interacts with: ptdins(3,4,5)P3, LYN, SYK, BLINK

UniGene
UniProt
Protein Databank
GSK3
GSK3

SYNkinase Products: SYN-1075

Involved in pathways: NF-kB, mTOR, BTK

Interacts with: AKT, NFAT

UniProt
Protein Databank
JNK
JNK

SYNkinase Products: SYN-1147, SYN-1028

Involved in pathways: TGFb/SMAD, MAP Kinase, GPCR, BTK

Interacts with: PKC

Protein Databank
P38 (alpha, beta, gamma, sigma)
P38 (alpha, beta, gamma, sigma)

SYNkinase Products: SYN-1101, SYN-1072, SYN-1073, SYN-1073A, SYN-1074, SYN-1076, SYN-1078, SYN-1079, SYN-1087, SYN-1093, SYN-1123

Involved in pathways: MAP Kinase, BTK, GPCR

Interacts with: Ca2+

Protein Databank
PKCalpha
PKCalpha

SYNkinase Products: SYN-1021, SYN-1037, SYN-1172

Involved in pathways: BTK

Interacts with: DAG, ERK,JNK

UniGene
UniProt
Protein Databank
SYK
SYK

SYNkinase Products: SYN-1121, SYN-1122

Involved in pathways: BTK

Interacts with: LYN, Igbeta, SHP1, BTK, BLINK, p85/p110 PI3K

UniGene
UniProt
Protein Databank
 Abl
Abl

SYNkinase Products: SYN-1095, SYN-1046, SYN-1061, SYN-1025, SYN-1036, SYN-1057, SYN-1116, SYN-1180A

Involved in pathways:

Interacts with: Cyclin D, CDK4,5, E2F, DP, Rb, HDAC, CDK2,

UniGene
UniProt
Protein Databank
Abl
Abl

SYNkinase Products: SYN-1095, SYN-1046, SYN-1061, SYN-1025, SYN-1036, SYN-1057, SYN-1116, SYN-1180A

Involved in pathways:

Interacts with: Cyclin D, CDK4,5, E2F, DP, Rb, HDAC, CDK2,

UniGene
UniProt
Protein Databank
ATM/ATR
ATM/ATR

SYNkinase Products: SYN-1051

Involved in pathways:

Interacts with: Chk1,2, BRACA1, FANCD2, NBS1, Abl

UniGene
UniProt
Aurora A
Aurora A

SYNkinase Products: SYN-1011, SYN-1034, SYN-1095, SYN-1048, SYN-1081, SYN-1092

Involved in pathways:

Interacts with: ARF

UniGene
UniProt
Protein Databank
CDK2
CDK2

SYNkinase Products: SYN-1110, SYN-1048, SYN-1040, SYN-1010, SYN-1151, SYN-1097, SYN-1070, SYN-1080, SYN-1180A

Involved in pathways:

Interacts with: Cyclin E, p21, CDC25A, Cyclin D, CDK4,5, Abl, E2F, DP, HDAC, Rb, Cyclin A, p21, p27

UniGene
UniProt
Protein Databank
CDK2
CDK2

SYNkinase Products: SYN-1110, SYN-1048, SYN-1040, SYN-1010, SYN-1151, SYN-1097, SYN-1070, SYN-1080, SYN-1180A

Involved in pathways:

Interacts with: Cyclin E, p21, CDC25A, Cyclin D, CDK4,5, Abl, E2F, DP, HDAC, Rb, Cyclin A, p21, p27

UniGene
UniProt
Protein Databank
CDK4,5
CDK4,5

SYNkinase Products: SYN-1110, SYN-1048, SYN-1040, SYN-1010, SYN-1151, SYN-1097, SYN-1070, SYN-1080, SYN-1180A

Involved in pathways:

Interacts with: P15,16,18,19, CDC25A, Cyclin D, E2F, DB

UniGene
UniProt
Protein Databank
CDK7
CDK7

SYNkinase Products: SYN-1110, SYN-1048, SYN-1040, SYN-1010, SYN-1151, SYN-1097, SYN-1070, SYN-1080, SYN-1180A

Involved in pathways:

Interacts with: Cyckin H, CDK2, Cyclin A

UniGene
UniProt
Protein Databank
Chk1
Chk1

SYNkinase Products: SYN-1174, SYN-1173, SYN-1174, SYN1189

Involved in pathways:

Interacts with: ATM, ATR, CDC25B/C

UniGene
UniProt
Protein Databank
Chk2
Chk2

SYNkinase Products: SYN-1174, SYN-1173

Involved in pathways:

Interacts with: ATM, ATR, CDC25B/C

UniGene
UniProt
Protein Databank
DNAPKcs
DNAPKcs

SYNkinase Products: SYN-1096

Interacts with: p53

UniGene
UniProt
Protein Databank
 BRaf
BRaf

SYNkinase Products: SYN-1069, SYN-1077, SYN-1161, SYN-1082

Involved in pathways: GPCR, Epigenetic

Interacts with: Epac, ERK

UniGene
UniProt
Protein Databank
JNK
JNK

SYNkinase Products: SYN-1147, SYN-1028

Involved in pathways: TGFb/SMAD, MAP Kinase, GPCR, BTK

Interacts with: RAS, SP1, c-JUN

Protein Databank
P38
P38

SYNkinase Products: SYN-1101, SYN-1072, SYN-1073, SYN-1073A, SYN-1074, SYN-1076, SYN-1078, SYN-1079, SYN-1087, SYN-1093, SYN-1123

Interacts with: RAS,

Protein Databank
PKA
PKA

SYNkinase Products: SYN-1110

Involved in pathways: NF-kB, GPCR

Interacts with: cAMP, Raf, Rap-1

Protein Databank
PKC
PKC

SYNkinase Products: SYN-1021, SYN-1037, SYN-1172

Involved in pathways: NF-kB, TGFb/SMAD, GPCR

Interacts with: PLCbeta, Raf

UniGene
UniProt
Protein Databank
PLCbeta
PLCbeta

SYNkinase Products: SYN-1172

Involved in pathways: GPCR

Interacts with: Galpha q, PKC

UniGene
UniProt
Raf
Raf

SYNkinase Products: SYN-1069, SYN-1077, SYN-1161, SYN-1082, SYN-1168

Involved in pathways: TGFb/SMAD, JAK-STAT, GPCR

Interacts with: PKC, PKA, RAS, ERK

UniGene
UniProt
Protein Databank
 ARaf
ARaf

SYNkinase Products: SYN-1069, SYN-1077, SYN-1161, SYN-1082

Involved in pathways: Epigenetic

Interacts with: RAS, MEK1/2

UniGene
UniProt
Protein Databank
BRaf
BRaf

SYNkinase Products: SYN-1069, SYN-1077, SYN-1161, SYN-1082

Involved in pathways: GPCR, Epigenetic

Interacts with: RAS, MEK1/2

UniGene
UniProt
Protein Databank
CDK4
CDK4

SYNkinase Products: SYN-1110, SYN-1048, SYN-1040, SYN-1010, SYN-1151, SYN-1097, SYN-1070, SYN-1080, SYN-1180A

Involved in pathways: Epigenetic

Interacts with: ERK1/2, Cyclin D

UniGene
UniProt
Protein Databank
CRaf
CRaf

SYNkinase Products: SYN-1069, SYN-1077, SYN-1161, SYN-1082

Involved in pathways: Epigenetic

Interacts with: RAS, MEK1/2

Protein Databank
EGFR
EGFR

SYNkinase Products: SYN-1012, SYN-1030, SYN-1039, SYN-1042, SYN-1100, SYN-1142, SYN-1052, SYN-1140, SYN-1141, SYN-1153, SYN-1090, SYN-1192

Involved in pathways: JAK-STAT, Epigenetic

Interacts with: EGF, GRB2

UniGene
UniProt
Protein Databank
FGFR
FGFR

SYNkinase Products: SYN-1095, SYN-1134, SYN-1135, SYN-1152, SYN-1084, SYN-1029, SYN-1038, SYN-1091, SYN-1149, SYN-1116, SYN-1085, SYN-1176

Involved in pathways: Epigenetic

Interacts with: FGF, GRB2

UniGene
UniProt
HER2
HER2

SYNkinase Products: SYN-1012, SYN-1100, SYN-1142, SYN-1052, SYN-1140, SYN-1141, SYN-1153, SYN-1033, SYN-1112, SYN-1192

Involved in pathways: Epigenetic

Interacts with: HRG, GRB2

Protein Databank
MEK1/2
MEK1/2

SYNkinase Products: SYN-1031, SYN-1170, SYN-1059, SYN-1016, SYN-1188, SYN-1190, SYN-1195

Interacts with: ARaf, BRaf, CRaf, ERK1/2

UniGene
UniProt
Protein Databank
PDGFR
PDGFR

SYNkinase Products: SYN-1003, SYN-1058, SYN-1058A, SYN-1056, SYN-1014, SYN-1138, SYN-1029, SYN-1091, SYN-1002, SYN-1055, SYN-1057, SYN-1169, SYN-1085, SYN-1086, SYN-1088, SYN-1053

Involved in pathways: Epigenetic

Interacts with: PDGF, GRB2

UniGene
UniProt
Protein Databank
RSK1-3
RSK1-3

SYNkinase Products: SYN-1020

Involved in pathways: MAP Kinase, Epigenetic

Interacts with: ERK1/2

UniGene
UniProt
Protein Databank